Abstract

Opinion

Insights from selected ancient Mesopotamian medicinal plants: an opinion piece

Jo Ann Scurlock*

Published: 08 June, 2023 | Volume 7 - Issue 2 | Pages: 020-026

This paper is grounded in a series of medical texts that survive from ancient Mesopotamia. It seeks to show the relevance of these texts for the modern researcher. Key findings are that the ancient Mesopotamian physician had already discovered many of the herbal treatments currently being verified by modern science. Armed with what these ancient texts tell us, we are in a position to offer advice on ways to ensure the most effective use of and avoid the dangers presented by selected medicinal plants.

Read Full Article HTML DOI: 10.29328/journal.jpsp.1001101 Cite this Article Read Full Article PDF

Keywords:

Turmeric; Licorice; Ancient Mesopotamia; Fumigation

References

  1. Scurlock JA. Sourcebook for ancient Mesopotamian medicine. Writings from the Ancient World 36. Atlanta: SBL Press; 2014.
  2. Scurlock JA, Andersen BR. Diagnoses in Assyrian and Babylonian medicine. Urbana: University of Illinois Press; 2005.
  3. Scurlock JA. A proposal for identification of a missing plant: Kamantu/ÁB.DUḪ = Lawsonia inermis L./“henna”. Wiener Zeitschrift für die Kunde des Morgenlandes 2007;97:491-520.
  4. Scurlock JA. Blind mice and despairing rats: The uses of kurkanû-turmeric in ancient and modern medicine. Journal des médicines cunéiformes. 2020;35:34-68.
  5. Scurlock JA. The effectiveness of ancient Mesopotamian medical practices: The example of šūšu-licorice. In: Jawad LA, editor. Tigris and Euphrates Rivers: their environment from headwaters to mouth. Aquatic Ecology Series 11; 2021;1:127-167. https://doi.org/10.1007/978-3-030-57570-0_5.
  6. Stadhouders H. The pharmacopoeial handbook Sammu sikinsu--an edition. J Med Cuneif. 2011;(18):3-51. PMID: 22586861.
  7. Stadhouders H. The pharmacopoeial handbook Šammu šikinšu—A translation. Journal of Cuneiform Medicines. 2012;19:1-21.
  8. Scurlock JA. An ancient Mesopotamian herbal handbook: The series URU.AN.NA and MÚD-UR.MAḪ. Forthcoming.
  9. Grayson AK, Novotny J. The royal inscriptions of Sennacherib, king of Assyria (704-681 BC), Part 1. The Royal Inscriptions of the Neo-Assyrian Period Volume 3/1. Winona Lake: Eisenbrauns; 2012.
  10. Toray Industries. Report on the analyses of textiles uncovered at the Nimrud tomb-chamber. Al-Rafidan. 1996;17:199-206.
  11. Campbell-Thompson R. A dictionary of Assyrian botany. London: The British Academy. 1949.
  12. Matteucci A, Frank C, Domenici MR, Balduzzi M, Paradisi S, Carnovale-Scalzo G, Scorcia G, Malchiodi-Albedi F. Curcumin treatment protects rat retinal neurons against excitotoxicity: effect on N-methyl-D: -aspartate-induced intracellular Ca(2+) increase. Exp Brain Res. 2005 Dec;167(4):641-8. doi: 10.1007/s00221-005-0068-0. Epub 2005 Aug 3. PMID: 16078027.
  13. Sun J, Chen F, Braun C, Zhou YQ, Rittner H, Tian YK, Cai XY, Ye DW. Role of curcumin in the management of pathological pain. Phytomedicine. 2018 Sep 15;48:129-140. doi: 10.1016/j.phymed.2018.04.045. Epub 2018 Apr 17. PMID: 30195871.
  14. Lee KK, Omiya Y, Yuzurihara M, Kase Y, Kobayashi H. Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix. J Ethnopharmacol. 2013 Jan 9;145(1):286-93. doi: 10.1016/j.jep.2012.11.005. Epub 2012 Nov 17. Erratum in: J Ethnopharmacol. 2013 Mar 7;146(1):431. PMID: 23164761.
  15. Kim SW, Lim CM, Lee HK, Lee JK. The use of Stronger Neo-Minophagen C, a glycyrrhizin-containing preparation, in robust neuroprotection in the postischemic brain. Anat Cell Biol. 2011 Dec;44(4):304-13. doi: 10.5115/acb.2011.44.4.304. Epub 2011 Dec 30. PMID: 22254159; PMCID: PMC3254884.
  16. Chigurupati H, Auddy B, Biyani M, Stohs SJ. Hepatoprotective Effects of a Proprietary Glycyrrhizin Product during Alcohol Consumption: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. Phytother Res. 2016 Dec;30(12):1943-1953. doi: 10.1002/ptr.5699. Epub 2016 Aug 19. PMID: 27539273.
  17. Hosseinzadeh H, Nassiri-Asl M. Pharmacological Effects of Glycyrrhiza spp. and Its Bioactive Constituents: Update and Review. Phytother Res. 2015 Dec;29(12):1868-86. doi: 10.1002/ptr.5487. Epub 2015 Oct 13. PMID: 26462981.
  18. Jia YX, Li JR, Mao CY, Yin WT, Jiang RH. Glycyrrhizin improves p75NTR-associated sciatic nerve regeneration in a BALB/c mouse model. Exp Ther Med. 2014 May;7(5):1141-1146. doi: 10.3892/etm.2014.1546. Epub 2014 Feb 14. PMID: 24940400; PMCID: PMC3991491.
  19. Bensch K, Tiralongo J, Schmidt K, Matthias A, Bone KM, Lehmann R, Tiralongo E. Investigations into the antiadhesive activity of herbal extracts against Campylobacter jejuni. Phytother Res. 2011 Aug;25(8):1125-32. doi: 10.1002/ptr.3384. Epub 2011 Jan 31. PMID: 21280113.
  20. Aleixo de Carvalho LS, Geraldo RB, de Moraes J, Silva Pinto PL, de Faria Pinto P, Pereira Odos S Jr, Da Silva Filho AA. Schistosomicidal activity and docking of Schistosoma mansoni ATPDase 1 with licoflavone B isolated from Glycyrrhiza inflata (Fabaceae). Exp Parasitol. 2015 Dec;159:207-14. doi: 10.1016/j.exppara.2015.09.015. Epub 2015 Oct 8. PMID: 26454044.
  21. Huang KC, Williams WM. The pharmacology of Chinese herbs. Boca Raton: CRC Press. 1993.
  22. Jung JC, Lee YH, Kim SH, Kim KJ, Kim KM, Oh S, Jung YS. Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease. BMC Complement Altern Med. 2016 Jan 22;16:19. doi: 10.1186/s12906-016-0997-0. PMID: 26801973; PMCID: PMC4722619.
  23. Kim KR, Jeong CK, Park KK, Choi JH, Park JH, Lim SS, Chung WY. Anti-inflammatory effects of licorice and roasted licorice extracts on TPA-induced acute inflammation and collagen-induced arthritis in mice. J Biomed Biotechnol. 2010;2010:709378. doi: 10.1155/2010/709378. Epub 2010 Mar 17. PMID: 20300198; PMCID: PMC2841253.
  24. Huang QC, Wang MJ, Chen XM, Yu WL, Chu YL, He XH, Huang RY. Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis? Oncotarget. 2016 Jan 12;7(2):1193-202. doi: 10.18632/oncotarget.6200. PMID: 26498361; PMCID: PMC4811453.
  25. Chen X, Fang D, Li L, Chen L, Li Q, Gong F, Fang M. Glycyrrhizin ameliorates experimental colitis through attenuating interleukin-17-producing T cell responses via regulating antigen-presenting cells. Immunol Res. 2017 Jun;65(3):666-680. doi: 10.1007/s12026-017-8894-2. PMID: 28108937.
  26. Chowdhury B, Bhattamisra SK, Das MC. Anti-convulsant action and amelioration of oxidative stress by Glycyrrhiza glabra root extract in pentylenetetrazole- induced seizure in albino rats. Indian J Pharmacol. 2013 Jan-Feb;45(1):40-3. doi: 10.4103/0253-7613.106433. PMID: 23543836; PMCID: PMC3608293.
  27. Luo L, Jin Y, Kim ID, Lee JK. Glycyrrhizin suppresses HMGB1 inductions in the hippocampus and subsequent accumulation in serum of a kainic acid-induced seizure mouse model. Cell Mol Neurobiol. 2014 Oct;34(7):987-97. doi: 10.1007/s10571-014-0075-4. Epub 2014 Jun 12. PMID: 24919651.
  28. Kim SW, Jin Y, Shin JH, Kim ID, Lee HK, Park S, Han PL, Lee JK. Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion. Neurobiol Dis. 2012 Apr;46(1):147-56. doi: 10.1016/j.nbd.2011.12.056. Epub 2012 Jan 13. PMID: 22266336.
  29. Jiang L, Wang Q, Shen S, Xiao T, Li Y. Discovery of glycyrrhetinic acid as an orally active, direct inhibitor of blood coagulation factor xa. Thromb Res. 2014 Mar;133(3):501-6. doi: 10.1016/j.thromres.2013.12.025. Epub 2013 Dec 22. PMID: 24412029.
  30. Tang E, Eisenbrand G. Chinese drugs of plant origin: Chemistry, pharmacology, and use in traditional and modern medicine. Berlin: Springer-Verlag. 1992.
  31. Cooper H, Bhattacharya B, Verma V, McCulloch AJ, Smellie WS, Heald AH. Liquorice and soy sauce, a life-saving concoction in a patient with Addison's disease. Ann Clin Biochem. 2007 Jul;44(Pt 4):397-9. doi: 10.1258/000456307780945624. PMID: 17594790.
  32. Majno G. The healing hand: Man and wound in the ancient world. Cambridge: Harvard University Press. 1975.
  33. Madhyastha R, Madhyastha H, Nakajima Y, Omura S, Maruyama M. Curcumin facilitates fibrinolysis and cellular migration during wound healing by modulating urokinase plasminogen activator expression. Pathophysiol Haemost Thromb. 2010;37(2-4):59-66. doi: 10.1159/000321375. Epub 2010 Nov 12. PMID: 21071923.
  34. Sidhu GS, Mani H, Gaddipati JP, Singh AK, Seth P, Banaudha KK, Patnaik GK, Maheshwari RK. Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair Regen. 1999 Sep-Oct;7(5):362-74. doi: 10.1046/j.1524-475x.1999.00362.x. PMID: 10564565.
  35. Konduru AS, Matsuyama S, Lee BC, Komatsu K, Li JD. Curcumin Inhibits NTHi-Induced MUC5AC Mucin Overproduction in Otitis Media via Upregulation of MAPK Phosphatase MKP-1. Int J Inflam. 2017;2017:4525309. doi: 10.1155/2017/4525309. Epub 2017 Apr 12. PMID: 28487811; PMCID: PMC5405397.
  36. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: A randomized controlled trial. Phytother Res. 2020 Jun;34(6):1446-1454. doi: 10.1002/ptr.6620. Epub 2020 Feb 3. PMID: 32017253.
  37. Ng ZY, Wong JY, Panneerselvam J, Madheswaran T, Kumar P, Pillay V, Hsu A, Hansbro N, Bebawy M, Wark P, Hansbro P, Dua K, Chellappan DK. Assessing the potential of liposomes loaded with curcumin as a therapeutic intervention in asthma. Colloids Surf B Biointerfaces. 2018 Dec 1;172:51-59. doi: 10.1016/j.colsurfb.2018.08.027. Epub 2018 Aug 16. PMID: 30134219.
  38. Srivilai J, Waranuch N, Tangsumranjit A, Khorana N, Ingkaninan K. Germacrone and sesquiterpene-enriched extracts from Curcuma aeruginosa Roxb. increase skin penetration of minoxidil, a hair growth promoter. Drug Deliv Transl Res. 2018 Feb;8(1):140-149. doi: 10.1007/s13346-017-0447-7. PMID: 29159692.
  39. Aldebasi YH, Aly SM, Rahmani AH. Therapeutic implications of curcumin in the prevention of diabetic retinopathy via modulation of anti-oxidant activity and genetic pathways. Int J Physiol Pathophysiol Pharmacol. 2013 Dec 15;5(4):194-202. PMID: 24379904; PMCID: PMC3867697.
  40. Grover M, Shah K, Khullar G, Gupta J, Behl T. Investigation of the utility of Curcuma caesia in the treatment of diabetic neuropathy. J Pharm Pharmacol. 2019 May;71(5):725-732. doi: 10.1111/jphp.13075. Epub 2019 Feb 14. PMID: 30767224.
  41. Rao PS, Ramanjaneyulu YS, Prisk VR, Schurgers LJ. A Combination of Tamarindus indicaseeds and Curcuma longa Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity. Int J Med Sci. 2019 Jun 2;16(6):845-853. doi: 10.7150/ijms.32505. PMID: 31337958; PMCID: PMC6643110.
  42. Chauhan PS, Singh DK, Dash D, Singh R. Intranasal curcumin regulates chronic asthma in mice by modulating NF-ĸB activation and MAPK signaling. Phytomedicine. 2018 Dec 1;51:29-38. doi: 10.1016/j.phymed.2018.06.022. Epub 2018 Jun 21. PMID: 30466625.
  43. Chun S, Muthu M, Gansukh E, Thalappil P, Gopal J. The ethanopharmacological aspect of carbon nanodots in turmeric smoke. Sci Rep. 2016 Nov 2;6:35586. doi: 10.1038/srep35586. PMID: 27805007; PMCID: PMC5090208.
  44. Sreenivasan S, Thirumalai K, Krishnakumar S. Expression profile of genes regulated by curcumin in Y79 retinoblastoma cells. Nutr Cancer. 2012;64(4):607-16. doi: 10.1080/01635581.2012.669875. Epub 2012 Apr 10. PMID: 22489823.
  45. Li Y, Sun W, Han N, Zou Y, Yin D. Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway. BMC Cancer. 2018 Dec 10;18(1):1230. doi: 10.1186/s12885-018-5130-y. PMID: 30526546; PMCID: PMC6288931.
  46. Yu X, Zhong J, Yan L, Li J, Wang H, Wen Y, Zhao Y. Curcumin exerts antitumor effects in retinoblastoma cells by regulating the JNK and p38 MAPK pathways. Int J Mol Med. 2016 Sep;38(3):861-8. doi: 10.3892/ijmm.2016.2676. Epub 2016 Jul 13. PMID: 27432244.
  47. Saikia S, Bordoloi M, Sarmah R, Kolita B. Antiviral compound screening, peptide designing, and protein network construction of influenza a virus (strain a/Puerto Rico/8/1934 H1N1). Drug Dev Res. 2019 Feb;80(1):106-124. doi: 10.1002/ddr.21475. Epub 2018 Oct 1. PMID: 30276835.
  48. Sornpet B, Potha T, Tragoolpua Y, Pringproa K. Antiviral activity of five Asian medicinal pant crude extracts against highly pathogenic H5N1 avian influenza virus. Asian Pac J Trop Med. 2017 Sep;10(9):871-876. doi: 10.1016/j.apjtm.2017.08.010. Epub 2017 Sep 14. PMID: 29080615.
  49. Boonmuen N, Gong P, Ali Z, Chittiboyina AG, Khan I, Doerge DR, Helferich WG, Carlson KE, Martin T, Piyachaturawat P, Katzenellenbogen JA, Katzenellenbogen BS. Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities. Steroids. 2016 Jan;105:42-9. doi: 10.1016/j.steroids.2015.11.006. Epub 2015 Nov 26. PMID: 26631549; PMCID: PMC4714869.
  50. Ahmed HM, Yeh JY, Tang YC, Cheng WT, Ou BR. Molecular screening of Chinese medicinal plants for progestogenic and anti-progestogenic activity. J Biosci. 2014 Jun;39(3):453-61. doi: 10.1007/s12038-014-9434-z. PMID: 24845509.

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